Abstract: St. Luke's United Methodist Church, 1858-2001, is located on the North Side of La Crosse, Wisconsin. The congregation, begun in 1856 under the name La Crosse Second Church and later known as the Caledonia Street Methodist Church, is still active and is affiliated with the United Methodists.

Records include historical materials, including photographs, clippings and historical booklets, as well as materials related to buildings and grounds, Christian Education, events, financial materials, membership, a few sacramental records (1897-1918), church clubs, the West Wisconsin Methodist Conference, and the Bice Family (a family with a long association with the church).